Gene Expression Literature Summary

Summary by Gene and Reference: Number indicates the number of results matching the search criteria recorded for each reference.
* Indicates detailed expression data entries available

Kdr  kinase insert domain protein receptor   (Synonyms: Flk1, Flk-1, orv, vascular endothelial growth factor receptor- 2, VEGFR2, VEGFR-2, VEGF receptor-2)
Results	Reference
1	J:32219 Carmeliet P, Ferreira V, Breier G, Pollefeyt S, Kieckens L, Gertsenstein M, Fahrig M, Vandenhoeck A, Harpal K, Eberhardt C, Declercq C, Pawling J, Moons L, Collen D, Risau W, Nagy A, Abnormal blood vessel development and lethality in embryos lacking a single VEGF allele. Nature. 1996 Apr 4;380(6573):435-9
1*	J:53293 Chang H, Huylebroeck D, Verschueren K, Guo Q, Matzuk MM, Zwijsen A, Smad5 knockout mice die at mid-gestation due to multiple embryonic and extraembryonic defects. Development. 1999 Apr;126(8):1631-42
1*	J:56817 Devic E, Rizzoti K, Bodin S, Knibiehler B, Audigier Y, Amino acid sequence and embryonic expression of msr/apj, the mouse homolog of Xenopus X-msr and human APJ. Mech Dev. 1999 Jun;84(1-2):199-203
1*	J:74909 Gerety SS, Anderson DJ, Cardiovascular ephrinB2 function is essential for embryonic angiogenesis. Development. 2002 Mar;129(6):1397-410
1	J:54197 Giroux S, Tremblay M, Bernard D, Cardin-Girard JF, Aubry S, Larouche L, Rousseau S, Huot J, Landry J, Jeannotte L, Charron J, Embryonic death of Mek1-deficient mice reveals a role for this kinase in angiogenesis in the labyrinthine region of the placenta. Curr Biol. 1999 Apr 8;9(7):369-72
1	J:215739 Kazanskaya O, Ohkawara B, Heroult M, Wu W, Maltry N, Augustin HG, Niehrs C, The Wnt signaling regulator R-spondin 3 promotes angioblast and vascular development. Development. 2008 Nov;135(22):3655-64
1	J:243177 Lania G, Ferrentino R, Baldini A, TBX1 Represses Vegfr2 Gene Expression and Enhances the Cardiac Fate of VEGFR2+ Cells. PLoS One. 2015;10(9):e0138525
1*	J:36300 Millauer B, Wizigmann-Voos S, Schnurch H, Martinez R, Moller NP, Risau W, Ullrich A, High affinity VEGF binding and developmental expression suggest Flk-1 as a major regulator of vasculogenesis and angiogenesis. Cell. 1993 Mar 26;72(6):835-46
1	J:85367 Park KW, Morrison CM, Sorensen LK, Jones CA, Rao Y, Chien CB, Wu JY, Urness LD, Li DY, Robo4 is a vascular-specific receptor that inhibits endothelial migration. Dev Biol. 2003 Sep 1;261(1):251-67
1*	J:45679 Peterson RS, Lim L, Ye H, Zhou H, Overdier DG, Costa RH, The winged helix transcriptional activator HFH-8 is expressed in the mesoderm of the primitive streak stage of mouse embryos and its cellular derivatives. Mech Dev. 1997 Dec;69(1-2):53-69
1*	J:50582 Roebroek AJ, Umans L, Pauli IG, Robertson EJ, van Leuven F, Van de Ven WJ , Constam DB, Failure of ventral closure and axial rotation in embryos lacking the proprotein convertase Furin. Development. 1998 Dec;125(24):4863-76
1	J:186931 Saito Y, Kojima T, Takahashi N, Mab21l2 is essential for embryonic heart and liver development. PLoS One. 2012;7(3):e32991
1*	J:201042 Saito Y, Kojima T, Takahashi N, The septum transversum mesenchyme induces gall bladder development. Biol Open. 2013 Aug 15;2(8):779-88
1	J:53304 Schorpp-Kistner M, Wang ZQ, Angel P, Wagner EF, JunB is essential for mammalian placentation. EMBO J. 1999 Feb 15;18(4):934-48
1*	J:65292 Schreiber M, Wang Z, Jochum W, Fetka I, Elliott C, Wagner EF, Placental vascularisation requires the AP-1 component fra1. Development. 2000 Nov;127(22):4937-48
1	J:132583 Stankunas K, Hang CT, Tsun ZY, Chen H, Lee NV, Wu JI, Shang C, Bayle JH, Shou W, Iruela-Arispe ML, Chang CP, Endocardial Brg1 represses ADAMTS1 to maintain the microenvironment for myocardial morphogenesis. Dev Cell. 2008 Feb;14(2):298-311
1*	J:166614 Stankunas K, Ma GK, Kuhnert FJ, Kuo CJ, Chang CP, VEGF signaling has distinct spatiotemporal roles during heart valve development. Dev Biol. 2010 Nov 15;347(2):325-36
1	J:132526 Unezaki S, Horai R, Sudo K, Iwakura Y, Ito S, Ovol2/Movo, a homologue of Drosophila ovo, is required for angiogenesis, heart formation and placental development in mice. Genes Cells. 2007 Jun;12(6):773-85
1*	J:65521 Urness LD, Sorensen LK, Li DY, Arteriovenous malformations in mice lacking activin receptor-like kinase-1. Nat Genet. 2000 Nov;26(3):328-31
1	J:104372 van Nes J, de Graaff W, Lebrin F, Gerhard M, Beck F, Deschamps J, The Cdx4 mutation affects axial development and reveals an essential role of Cdx genes in the ontogenesis of the placental labyrinth in mice. Development. 2006 Feb;133(3):419-28
1	J:70892 Ylikorkala A, Rossi DJ, Korsisaari N, Luukko K, Alitalo K, Henkemeyer M, Makela TP, Vascular abnormalities and deregulation of VEGF in Lkb1-deficient mice. Science. 2001 Aug 17;293(5533):1323-6